Superdisintegrant on Disintegrant and Dissolution; a Review on Influence
نویسندگان
چکیده
In tablet formulation superdisintegrants are added to accelerate the rate of tablet deaggregation and thus enhancing the rate of tablet dissolution. In this review article we gather the information related to the superdisintegrants, their mechanism of actions and their impact on disintegration and dissolution processes. The easiest way to achieve quick release is to use a superdisintegrants with appropriate concentrations of excipients. Different superdisintegrants are usually added to facilitate the tablet disintegration, thus increasing the rate of tablet dissolution. 1. Faculty of Pharmacy, Ziauddin University Karachi, Pakistan. 2. Faculty of Pharmacy, Ziauddin University Karachi, Pakistan. 3. Faculty of Pharmacy, Ziauddin University Karachi, Pakistan. 2. Faculty of Medicine, Ziauddin Medical College, Ziauddin University, Karachi, Pakistan 5. Faculty of Pharmacy, Ziauddin University Karachi, Pakistan. 6. Faculty of Pharmacy, Ziauddin University Karachi, Pakistan. 7. Faculty of Pharmacy, Ziauddin University Karachi, Pakistan. Correspondence Address: Huma Ali Faculty of Pharmacy, Ziauddin University Karachi, Pakistan. Article received on: 21/04/2016 Accepted for publication: 30/07/2016 Received after proof reading: 07/10/2016 Article Citation: Qureshi MS, Zafar F, Ali H, Hameed K, Mallick N, Khan S, Baloch SA. Superdisintegrant on disintegrant and dissolution; A review on influence. Professional Med J 2016;23(10):1167-1170. DOI: 10.17957/TPMJ/16.3413 INTRODUCTION Tablets and capsules are amongst the list of solid oral dosage form. To achieve desired dosage form with required efficacy, the powders (excipients and active pharmaceutical ingredient) must be blended properly in order to obtain uniformity.1 Tablets have a wide range of advantages for patients and manufacturers.2 Advantages of tablets • Tablets are single dosage form with a dose precision. • It is considered to be a cost effective dosage form. • A large batch size can easily be manufactured.2 • Chances of microbial contamination are reduced due to less moisture content exposure. • Variety of sub doses is also available for example buccal, floating targeting colon and dispersible formulations etc.3 Effects of Superdisintegrants The gastrointestinal tract offers sufficient amount of gastrointestinal fluid to accelerate the dispersion of the tablet dosage form. Scientists reported that almost 90% of all compounds may produce systemic response when they are administered orally. Furthermore, the drug release rate is accelerated by the rapid disintegration of the tablet.4 The easiest way to achieve quick release is to use a superdisintegrants with appropriate concentrations of excipients. Different superdisintegrants are usually added to facilitate the tablet disintegration, thus increasing the rate of tablet dissolution.5 The selection of a suitable kind and quantity of superdisintegrants is very important for the fast deaggregation of tablets. Also different physicochemical features of excipients can affect the rate of the tablet deaggregation. Various investigators have reported that superdisintegrants had a significant effect on deaggregation time in insoluble systems. Furthermore, the solubility of the tablet formulation in directly compressed DOI: 10.17957/TPMJ/16.3413
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